Endocrine Abstracts

Introduction: Kisspeptin is a 54-amino acid peptide, which comprise a diverse group of peptides with many different functions related to energy metabolism and reproduction, pubertal development. It activates GPR54 receptor. Subcutaneous administration of kisspeptin-54 to women with regular menstrual cycles results in an increase in LH and FSH. All these findings show that the GPR54 system may play a role in the function of the hypothalamic–pituitary–gonadal axis. PCO...

Introduction: Majority of polycystic ovary syndrome (PCOS) women are anovulatory, overweight/obese and insulin resistant. Kisspeptins are the endogenous ligands for GPR54 highly expressed in pancreas. Some studies showed that kisspeptins may play in the regulation of islet function and they stimulate insulin secretion from mouse and human islets. Adipose tissue acts as an endocrine organ and its function may be regulated by kisspeptins. We designed this study based on that obe...

Introduction: Generously supported by IPSEN)-->Acromegaly is a rare, chronic disorder, with classical clinical features caused by excess GH and consequent raised levels IGF1 and is associated with increased morbidity and mortality. Early diagnosis of the disease is very important for patient survival. Fetuin-A is a plasma glycoprotein that is produced by hepatocytes and it is the most important systemic calcification inhibitor. The p...

Introduction: Generously supported by IPSEN)-->Acromegaly is a rare, insidious, and potentially life-threatening condition. Patients with acromegaly have an increased morbidity and mortality for cardiovascular diseases. However, data on coronary heart disease and atherosclerosis are controversial in patients with acromegaly. Measurement of carotid intima media thickness (cIMT) with carotid doppler ultrasonography is a useful determin...

Introduction: Acromegaly is a rare disease that is most often caused by a GH secreting pituitary tumor. Apelin, a newly discovered peptide known as an endogenous ligand for its receptor (APJ) is a cardiac positive inotropic factor that has also hypotensive effects. The apelin and its receptor functions have not entirely been understood yet. The physiological importance of apelin, in acromegaly remains obscure.The aim of this study was to investigate the ...

Background and aim: As a prognostic marker, copeptin levels were independent predictors of survival in critically ill patients suffering from hemorrhagic and septic shock. Copeptin levels also have prognostic implications in chronic diseases other than acute illness. The stress-mediated activation of the HPA axis may be have role in the pathogenesis of the insulin resistance, metabolic syndrome, and diabetes. Furthermore, AVP action has been linked to liver glycogenolysis and ...